Newly Discovered Alzheimer's Gene

Scientists have discovered a new Alzheimer's Disease gene (quoted from SciAm):

"A newly identified genetic mutation increases the risk for the most common form of Alzheimer’s disease—the second major gene to be linked to the neurodegenerative disorder. The mutation occurs in the so-called CALHM1 gene, which controls calcium concentrations in nerve cells. Researchers observed that mutant CALHM1 led to increased accumulation of amyloid beta plaques, the sticky protein clumps characteristic of the disease. In the U.S.

Alzheimer’s affects one in 20 adults aged 65 to 74; carrying one defective copy of CALHM1 escalates the risk to one in 14 (and to one in 10 for those carrying two defective copies). The mutation also leads to an earlier age of onset. Reporting in the June 27 Cell, lead author Philippe Marambaud of the Feinstein Institute for Medical Research in Manhasset, N.Y., states that the CALHM1 gene—along with the first Alzheimer’s gene, APOE, discovered 15 years ago—will be important in screening for the disease."

I couldn't find a more comprehensive article on it on SciAm, but if I run across something I will post it here.

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